Assessment of Anti-Mutagenic, Anti-Histopathologic and Antioxidant
Capacities of Egyptian Bee Pollen and Propolis Extracts
Bee pollen and propolis are popular, traditional health
foods. The objective of the current study was to investigate the
anti-mutagenic, anti-histopathologic and antioxidant effects among water
extracts of Egyptian bee pollen (WEBP) and brown powder of water-soluble
derivative propolis (WSDP) on cisplatin (CDDP) induced hepatic, renal,
testicular and genotoxicity in male albino mice (Mus muscullus), in addition to
their effects on the oxidant/antioxidant status in the tested organs.
Hepatic, renal and testicular dysfunctions were evaluated
histologically; while genotoxicity and cytotoxicity were evaluated by the bone
marrow chromosomal aberration assay and mitotic index, respectively. Moreover,
oxidative stress was explored via determination of lipid peroxidation, catalase
activity and the concentration of the reduced form of glutathione.
The treatment of mice with WEBP and WSDP at doses 140 and
8.4 mg/kg b. wt./day, respectively for 14 days simultaneously with CDDP (2.8
mg/kg b. wt.) resulted in significant protection. The positive control animals
taken CDDP alone showed toxic histological and genetical manifestations (at P
On the basis of the present assays, Bee pollen appears more
potent in exerting an ameliorative effect and this effect was more pronounced
in testis.