Kalender next 42tg

Keine Termine

Event Kalender

März 2024
Mo Di Mi Do Fr Sa So
26 27 28 29 1 2 3
4 5 6 7 8 9 10
11 12 13 14 15 16 17
18 19 20 21 22 23 24
25 26 27 28 29 30 31

Banners


Oral Mucosal Adhesive Films Containing Royal Jelly Accelerate Recovery from 5-Fluorouracil-Induced Oral Mucositis

Oral mucositis induced by chemotherapy or radiotherapy has an impact upon quality-of-life, is dose-limiting for chemotherapy, and causes considerable morbidity. We evaluated the effect of royal jelly (RJ) on 5-fluorouracil (5-FU)-induced oral mucositis in hamsters. 

Oral mucositis was induced in hamsters through a combination of 5-FU treatment and mild abrasion of the cheek pouch. RJ was contained in chitosan-sodium alginate film (RJ film). Films were attached to the oral mucosa and the healing process examined by measuring the area of mucositis, myeloperoxidase (MPO) activity, microscopic aspects, and RT-PCR for detection of pro-inflammatory cytokines (tumor necrosis factor-α, interleukin-1β). Furthermore, we evaluated the radical-scavenging activity of RJ and generation of keratinocyte growth factor from human periodontal ligament fibroblasts. RJ films (10%, 30%) significantly improved recovery from 5-FU-induced damage, reduced MPO activity and the production of pro-inflammatory cytokines. Additionally, RJ showed radical-scavenging activity. 

These data suggest that topical application of films that contain RJ had a healing effect on the severe oral mucositis induced by 5-FU and that the effect was caused by the anti-inflammatory or anti-oxidative activities of RJ.

Apitherapy News

Phänologie

Agroscope - Imkerei
Das Zentrum für Bienenforschung ist Bestandteil der Forschungsanstalt  Agroscope Liebefeld-Posieu…
VSI - Verband Schwei…
VSI - Verband Schweizerischer Imkergerätehersteller und Imkereifachgeschäfte
More Links » JoelLipman.Com

aktualisierte Beiträge

Wetter

who is online

Aktuell sind 654 Gäste, 57 Bots und keine Mitglieder online


57 Bots:
27 x Googlebot
15 x AhrefsBot
14 x SemrushBot
1 x bingbot