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Titel Impact of Bee Venom Enzymes on Diseases and Immune Responses
Subtitel
Author Hossen, M.S.; Shapla, U.M.; Gan, S.H.; Khalil, M.I.
Abstract Bee venom (BV) is used to treat many diseases and exhibits anti-inflammatory, anti-bacterial, antimutagenic, radioprotective, anti-nociceptive immunity promoting, hepatocyte protective and anti-cancer activity. According to the literature, BV contains several enzymes, including phospholipase A2 (PLA2), phospholipase B, hyaluronidase, acid phosphatase and α-glucosidase. Recent studies have also reported the detection of different classes of enzymes in BV, including esterases, proteases and peptidases, protease inhibitors and other important enzymes involved in carbohydrate metabolism. Nevertheless, the physiochemical properties and functions of each enzyme class and their mechanisms remain unclear. Various pharmacotherapeutic effects of some of the BV enzymes have been reported in several studies. At present, ongoing research aims to characterize each enzyme and elucidate their specific biological roles. This review gathers all the current knowledge on BV enzymes and their specific mechanisms in regulating various immune responses and physiological changes to provide a basis for future therapies for various diseases
Methods
Results
Conclusions
dx.doi.org / URL doi.org/10.3390/molecules22010025
Published 
Molecules. 2017; 22(1):25. 
Attachments:
FileDescriptionFile sizeDownloads
Download this file (molecules-22-00025.pdf)molecules-22-00025.pdf 2005 kB2055
Titel Australian manuka honey a medicinal powerhouse
Subtitel The Antibacterial Activity of Australian Leptospermum Honey Correlates with Methylglyoxal Levels
Author  Cokcetin NN, et al.
Abstract
Australian manuka honey is at least as powerful against bacteria as the more commonly known New Zealand variety, researchers have found.

 
 

A team led by Professor Liz Harry at UTS has studied more than 80 honey samples from NSW and Queensland flowering manuka (Leptospermum) trees and found the nectar-derived chemical that gives NZ manuka honey its unique antibacterial properties is present in Australian varieties.

The ground-breaking research also shows the antibacterial properties of honey remain unchanged over several years when stored appropriately.

"These findings put Australian manuka honey on the international radar at a time when antibiotic resistance is recognised as a global crisis," said Dr Nural Cokcetin, of the ithree institute at UTS, a lead author of the study which also includes collaborators at the University of Sydney and the University of the Sunshine Coast.

"All honeys have different flavours and medicinal properties, depending on the flowers bees visit for nectar. What makes manuka honey so special is the exceptionally high level of stable antibacterial activity that arises from a naturally occurring compound in the nectar of manuka flowers. It's the ingredient we know acts against golden staph and other superbugs resistant to current antibiotics.
Methods
Results
Conclusions
dx.doi.org / URL
Published  PLoS ONE
Attachments:
FileDescriptionFile sizeDownloads
Download this file (2016-12-australian-manuka-honey-medicinal-powerhouse.pdf)2016-12-australian-manuka-honey-medicinal-powerhouse.pdf 173 kB1713
Download this file (plos.pdf)plos.pdf 1513 kB2328
Titel Hypocholesterolemic efficacy of royal jelly in healthy mild hypercholesterolemic adults
Subtitel
Author Hui-Fang Chiu, Bo-Kai Chen, Yan-Ying Lu, Yi-Chun Han, You-Cheng Shen, Kamesh Venkatakrishnan, Oksana Golovinskaia, and Chin-Kun Wang
Abstract Context: Royal jelly (RJ) has been reported for its health promoting factors such as antioxidant, anti-inflammatory and lipid lowering activities.

Objective: The present randomized, placebo-controlled study examines the hypolipidemic beneficial effect of RJ through evaluating anthropometric measurements, lipid profile and various hormone levels in mildly hypercholesterolemic participants.

Materials and methods: Forty subjects with mild hypercholesterolemia (180–200 mg/dL) were randomly selected and divided into two groups as experimental or placebo, who requested to intake nine capsules (350 mg/capsule) of RJ or placebo/day, respectively, for three months with one month of follow-up without any supplementation.

Results: No significant changes were noted in any of the anthropometric parameters like body weight, waist and body fat. The serum total cholesterol (TC; 207.05–183.15 mg/dL) and low-density lipoprotein cholesterol (LDL-c; 126.44–120.31 mg/dL) levels were reduced significantly (p < 0.05) after administration of RJ. However, triglyceride (TG) and high-density lipoprotein cholesterol (HDL-c) levels were not considerably altered. Moreover, three months of RJ consumption significantly ameliorated (p < 0.05) the concentration of sex hormones like dehydroepiandrosterone sulphate (DHEA-S; 1788.09–1992.31 ng/mL). Also, intake of RJ did not elicit any hepatic or renal damage.

Discussion and conclusion: Intervention with RJ for three months considerably lowered the TC and LDL-c levels through improving the levels of DHEA-S and thus alleviates the risk of cardiovascular disease (CVD).
Methods
Results
Conclusions
dx.doi.org / URL http://dx.doi.org/10.1080/13880209.2016.1253110
Published  Pharmaceutical Biology Volume 55, 2017 -  Issue 1
Attachments:
FileDescriptionFile sizeDownloads
Download this file (13880209.2016.1253110.pdf)13880209.2016.1253110.pdf 874 kB1685

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